| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KBTBD8 |
| Gene ID: | 84541 |
| Uniprot ID: | KBTB8_HUMAN |
| Immunogen Region: | 50-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-280 of human KBTBD8 (NP_115894.2). |
| Immunogen Sequence: | DIVVEVDHGKTFSCHRNVLA AISPYFRSMFTSGLTESTQK EVRIVGVEAESMDLVLNYAY TSRVILTEANVQALFTAASI FQIPSIQDQCAKYMISHLDP QNSIGVFIFADHYGHQELGD RSKEYIRKKFLCVTKEQEFL QLTKDQLISILDSDDLNVDR EEHVYESIIRWFEHEQNERE VHLPEIFAKCIRFPLMEDTF IEKIPPQFAQAIAKSCVEKG PSNTNGCTQRL |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. |
| Protein Name | Kelch Repeat And Btb Domain-Containing Protein 8T-Cell Activation Kelch Repeat ProteinTa-Krp |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleGolgi ApparatusTranslocates To The Spindle Apparatus During Mitosis |
| Alternative Antibody Names | Anti-Kelch Repeat And Btb Domain-Containing Protein 8 antibodyAnti-T-Cell Activation Kelch Repeat Protein antibodyAnti-Ta-Krp antibodyAnti-KBTBD8 antibodyAnti-KIAA1842 antibodyAnti-TAKRP antibody |
Information sourced from Uniprot.org