Anti-KATNA1 antibody (STJA0006932)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human KATNA1
General Information
| Short Description | Rabbit polyclonal anti-Katanin p60 ATPase-containing subunit A1 for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KATNA1 |
| Gene ID | 11104 |
| Uniprot ID | KTNA1_HUMAN |
| Immunogen | Synthesized peptide derived from human KATNA1 |
| Specificity | This antibody detects endogenous levels of KATNA1 at Human, Rat |
Additional Info
| Function | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
| Protein Name | Katanin P60 Atpase-Containing Subunit A1Katanin P60 Subunit A1P60 Katanin |
| Database Links | |
| Cellular Localisation | CytoplasmMidbodyCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindlePredominantly CytoplasmicLocalized Diffusely In The Cytoplasm During The InterphaseDuring Metaphase Is Localized Throughout The Cell And More Widely Dispersed Than The MicrotubulesIn Anaphase And Telophase Is Localized At The Midbody RegionAlso Localized To The Interphase Centrosome And The Mitotic Spindle PolesEnhanced Recruitment To The Mitotic Spindle Poles Requires Microtubules And Interaction With Katnb1Localizes Within The CytoplasmPartially Overlapping With MicrotubulesIn Interphase And To The Mitotic Spindle And Spindle Poles During Mitosis |
| Alternative Antibody Names | Anti-Katanin P60 Atpase-Containing Subunit A1 antibodyAnti-Katanin P60 Subunit A1 antibodyAnti-P60 Katanin antibodyAnti-KATNA1 antibody |
Information sourced from Uniprot.org