• Immunohistochemistry analysis of KATNA1 in paraffin-embedded mouse heart using KATNA1 Rabbit polyclonal antibody (STJ118918) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of KATNA1 in paraffin-embedded human tonsil using KATNA1 Rabbit polyclonal antibody (STJ118918) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of KATNA1 in paraffin-embedded rat heart using KATNA1 Rabbit polyclonal antibody (STJ118918) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-KATNA1 antibody (1-167) (STJ118918)

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STJ118918

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KATNA1 (1-167) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KATNA1
Gene ID: 11104
Uniprot ID: KTNA1_HUMAN
Immunogen Region: 1-167
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human KATNA1 (NP_001191005.1).
Immunogen Sequence: MSLLMISENVKLAREYALLG NYDSAMVYYQGVLDQMNKYL YSVKDTYLQQKWQQVWQEIN VEAKHVKDIMKTLESFKLDS TPLKAAQHDLPASEGEVWSM PVPVERRPSPGPRKRQSSQY SDPKSHGNRPSTTVRVHRSS AQNVHNDRGKAVRCREKKEQ NKGREEK
Post Translational Modifications Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation. Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
Function Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Protein Name Katanin P60 Atpase-Containing Subunit A1
Katanin P60 Subunit A1
P60 Katanin
Cellular Localisation Cytoplasm
Midbody
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle Pole
Spindle
Predominantly Cytoplasmic
Localized Diffusely In The Cytoplasm During The Interphase
During Metaphase Is Localized Throughout The Cell And More Widely Dispersed Than The Microtubules
In Anaphase And Telophase Is Localized At The Midbody Region
Also Localized To The Interphase Centrosome And The Mitotic Spindle Poles
Enhanced Recruitment To The Mitotic Spindle Poles Requires Microtubules And Interaction With Katnb1
Localizes Within The Cytoplasm
Partially Overlapping With Microtubules
In Interphase And To The Mitotic Spindle And Spindle Poles During Mitosis
Alternative Antibody Names Anti-Katanin P60 Atpase-Containing Subunit A1 antibody
Anti-Katanin P60 Subunit A1 antibody
Anti-P60 Katanin antibody
Anti-KATNA1 antibody

Information sourced from Uniprot.org

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