• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p300/CBP Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from COLO205 cells, using p300/CBP Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using PCAF Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-KAT2B antibody (783-832 aa) (STJ94980)

SKU:
STJ94980

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Histone acetyltransferase KAT2B (783-832 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KAT2B
Gene ID: 8850
Uniprot ID: KAT2B_HUMAN
Immunogen Region: 783-832 aa
Specificity: PCAF Polyclonal Antibody detects endogenous levels of PCAF protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human p300/CBP at the amino acid range 783-832
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis. Also acetylates spermidine. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Protein Name Histone Acetyltransferase Kat2b
Histone Acetyltransferase Pcaf
Histone Acetylase Pcaf
Lysine Acetyltransferase 2b
P300/Cbp-Associated Factor
P/Caf
Spermidine Acetyltransferase Kat2b
Database Links Reactome: R-HSA-1912408
Reactome: R-HSA-2032785
Reactome: R-HSA-210744
Reactome: R-HSA-2122947
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-3214847
Reactome: R-HSA-350054
Reactome: R-HSA-5250924
Reactome: R-HSA-5578768
Reactome: R-HSA-5689901
Reactome: R-HSA-73762
Reactome: R-HSA-8936459
Reactome: R-HSA-8941856
Reactome: R-HSA-9013508
Reactome: R-HSA-9013695
Reactome: R-HSA-9018519
Reactome: R-HSA-9617629
Reactome: R-HSA-9772755
Reactome: R-HSA-9793380
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Mainly Localizes To The Nucleus
Also Localizes To Centrosomes In Late G1 And Around The G1/S Transition
Coinciding With The Onset Of Centriole Formation
Subcellular Location May Vary Depending Upon Cell Differentiation State
Cytoplasmic At The Very Stages Of Keratinocyte Differentiation
Becomes Nuclear At Later Differentiation Stages
Cytoplasmic In Basal Epithelial Cells (Undifferentiated Cells) And Nuclear In Parabasal Cells (Differentiated Cells)
Localizes To Sites Of Dna Damage
Alternative Antibody Names Anti-Histone Acetyltransferase Kat2b antibody
Anti-Histone Acetyltransferase Pcaf antibody
Anti-Histone Acetylase Pcaf antibody
Anti-Lysine Acetyltransferase 2b antibody
Anti-P300/Cbp-Associated Factor antibody
Anti-P/Caf antibody
Anti-Spermidine Acetyltransferase Kat2b antibody
Anti-KAT2B antibody
Anti-PCAF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance