![Anti-Kappa Light Chain antibody [L1C1] (STJ16100380)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149097/346715/STJ16100380_1__90969.1681998803.jpg?c=1 "Anti-Kappa Light Chain antibody [L1C1] (STJ16100380)")
![Anti-Kappa Light Chain antibody [L1C1] (STJ16100380)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149097/346715/STJ16100380_1__90969.1681998803.jpg?c=1 "Anti-Kappa Light Chain antibody [L1C1] (STJ16100380)")
Anti-Kappa Light Chain antibody [L1C1] (STJ16100380)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-Kappa Light Chain for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | L1C1 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Dilution Range | IHC 1:100 – 1:500 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
Additional Info
| Background | The antibody detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1. |
Information sourced from Uniprot.org