Anti-KANK2 antibody (1-300) (STJ117615)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KANK2 (1-300) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KANK2 |
| Gene ID | 25959 |
| Uniprot ID | KANK2_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MAQVLHVPAPFPGTPGPASP PAFPAKDPDPPYSVETPYGY RLDLDFLKYVDDIEKGHTLR RVAVQRRPRLSSLPRGPGSW WTSTESLCSNASGDSRHSAY SYCGRGFYPQYGALETRGGF NPRVERTLLDARRRLEDQAA TPTGLGSLTPSAAGSTASLV GVGLPPPTPRSSGLSTPVPP SAGHLAHVREQMAGALRKLR QLEEQVKLIPVLQVKLSVLQ EEKRQLTVQLKSQKFLGHP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KANK2 (NP_001129663.1). |
Additional Info
| Tissue Specificity | Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). |
| Post Translational Modifications | Phosphorylated by casein kinase II upon estrogen stimulation. Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription. |
| Function | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation. |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2Ankyrin Repeat Domain-Containing Protein 25Matrix-Remodeling-Associated Protein 3Src-1-Interacting ProteinSipSrc-Interacting ProteinSrc1-Interacting Protein |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Kn Motif And Ankyrin Repeat Domain-Containing Protein 2 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 25 antibodyAnti-Matrix-Remodeling-Associated Protein 3 antibodyAnti-Src-1-Interacting Protein antibodyAnti-Sip antibodyAnti-Src-Interacting Protein antibodyAnti-Src1-Interacting Protein antibodyAnti-KANK2 antibodyAnti-ANKRD25 antibodyAnti-KIAA1518 antibodyAnti-MXRA3 antibodyAnti-SIP antibody |
Information sourced from Uniprot.org