Anti-Kalirin antibody (C-Term) (STJ70450)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Kalirin (C-Term) is suitable for use in ELISA, Flow Cytometry and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/FC/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary testing showed a band at approx.. 200kDa in Rat Brain lysate, after 0.1ug/ml antibody staining (calculated Mwt. of 192.5 kDa according to XP_038944588.1). Primary incubatio |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | KALRN |
| Gene ID | 8997 |
| Uniprot ID | KALRN_HUMAN |
| Accession Number | NP_003938.1; NP_001309918.1; NP_001309919.1; NP_001309920.1; NP_001309921.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RWHLGPGDPFSTYV |
| Specificity | This antibody is expected to recognise NP_003938.1; (isoform 2) , NP_001309918..1 (9isoform 5) , NP_001309919.1; (isoform 6) , NP_001309920.1 (isoform 7) , and NP_001309921.1 (isoform 8). |
Additional Info
| Post Translational Modifications | Autophosphorylated. |
| Function | Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. |
| Protein Name | KalirinHuntingtin-Associated Protein-Interacting ProteinProtein DuoSerine/Threonine-Protein Kinase With Dbl- And Pleckstrin Homology Domain |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-3928662Reactome: R-HSA-416476Reactome: R-HSA-416482Reactome: R-HSA-5687128Reactome: R-HSA-8980692Reactome: R-HSA-9013149Reactome: R-HSA-9013408 |
| Cellular Localisation | CytoplasmCytoskeletonAssociated With The Cytoskeleton |
| Alternative Antibody Names | Anti-Kalirin antibodyAnti-Huntingtin-Associated Protein-Interacting Protein antibodyAnti-Protein Duo antibodyAnti-Serine/Threonine-Protein Kinase With Dbl- And Pleckstrin Homology Domain antibodyAnti-KALRN antibodyAnti-DUET antibodyAnti-DUO antibodyAnti-HAPIP antibodyAnti-TRAD antibody |
Information sourced from Uniprot.org