Anti-Kaiso antibody [R01-3O4] (STJA0037210)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human KAISO
General Information
| Short Description | Rabbit monoclonal anti-Kaiso for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3O4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ZBTB33 |
| Gene ID | 10009 |
| Uniprot ID | KAISO_HUMAN |
| Immunogen | A synthesized peptide derived from human KAISO |
Additional Info
| Tissue Specificity | Expressed in vascular endothelium. |
| Function | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1. |
| Protein Name | Transcriptional Regulator KaisoZinc Finger And Btb Domain-Containing Protein 33 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmAlso Cytoplasmic In Cells Grown At High Densities |
| Alternative Antibody Names | Anti-Transcriptional Regulator Kaiso antibodyAnti-Zinc Finger And Btb Domain-Containing Protein 33 antibodyAnti-ZBTB33 antibodyAnti-KAISO antibodyAnti-ZNF348 antibody |
Information sourced from Uniprot.org