Anti-JTB antibody (31-105) (STJ112459)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal JTB (31-105) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JTB |
| Gene ID | 10899 |
| Uniprot ID | JTB_HUMAN |
| Immunogen Region | 31-105 |
| Immunogen Sequence | EAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKT TPECGPTGYVEKITCSSSKR NEFKSCRSALMEQRL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 31-105 of human JTB (NP_006685.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. |
| Function | Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. |
| Protein Name | Protein JtbJumping Translocation Breakpoint ProteinProstate Androgen-Regulated ProteinPar Protein |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinMitochondrionCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleDetected At The Centrosome And Along Spindle Fibers During Prophase And MetaphaseDetected At The Midbody During Telophase |
| Alternative Antibody Names | Anti-Protein Jtb antibodyAnti-Jumping Translocation Breakpoint Protein antibodyAnti-Prostate Androgen-Regulated Protein antibodyAnti-Par Protein antibodyAnti-JTB antibodyAnti-HSPC222 antibody |
Information sourced from Uniprot.org