Anti-JTB antibody (100-146) {Biotin} (STJ505927)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 100-146 on human Jumping Translocation Breakpoint protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-JTB (100-146) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5-1.5 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | JTB |
| Gene ID | 10899 |
| Uniprot ID | JTB_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 100-146 on human Jumping Translocation Breakpoint protein. |
| Immunogen Region | 100-146 |
Additional Info
| Function | Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. |
| Protein Name | Protein JtbJumping Translocation Breakpoint ProteinProstate Androgen-Regulated ProteinPar Protein |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinMitochondrionCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleDetected At The Centrosome And Along Spindle Fibers During Prophase And MetaphaseDetected At The Midbody During Telophase |
| Alternative Antibody Names | Anti-Protein Jtb antibodyAnti-Jumping Translocation Breakpoint Protein antibodyAnti-Prostate Androgen-Regulated Protein antibodyAnti-Par Protein antibodyAnti-JTB antibodyAnti-HSPC222 antibody |
Information sourced from Uniprot.org