Anti-JTB antibody (10-59 aa) (STJ93809)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human JTB at the amino acid range 10-59
General Information
| Short Description | Rabbit polyclonal anti-Protein JTB (10-59 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JTB |
| Gene ID | 10899 |
| Uniprot ID | JTB_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human JTB at the amino acid range 10-59 |
| Immunogen Region | 10-59 aa |
| Specificity | JTB Polyclonal Antibody detects endogenous levels of JTB protein. |
Additional Info
| Function | Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. |
| Protein Name | Protein JtbJumping Translocation Breakpoint ProteinProstate Androgen-Regulated ProteinPar Protein |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinMitochondrionCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleDetected At The Centrosome And Along Spindle Fibers During Prophase And MetaphaseDetected At The Midbody During Telophase |
| Alternative Antibody Names | Anti-Protein Jtb antibodyAnti-Jumping Translocation Breakpoint Protein antibodyAnti-Prostate Androgen-Regulated Protein antibodyAnti-Par Protein antibodyAnti-JTB antibodyAnti-HSPC222 antibody |
Information sourced from Uniprot.org