Anti-JPT1 antibody (50-154) [S5147RM] (STJ11105147)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Jupiter Microtubule Associated Homolog 1 (50-154) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5147RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JPT1 |
| Gene ID | 51155 |
| Uniprot ID | JUPI1_HUMAN |
| Immunogen Region | 50-154 |
| Immunogen Sequence | NIFGTPEENQASWAKSAGAK SSGGREDLESSGLQRRNSSE ASSGDFLDLKGEGDIHENVD TDLPGSLGQSEEKPVPAAPV PSPVAPAPVPSRRNPPGGKS SLVLG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-154 of human HN1 (NP_057269.1). |
Additional Info
| Tissue Specificity | Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta. |
| Function | Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation. |
| Protein Name | Jupiter Microtubule Associated Homolog 1Androgen-Regulated Protein 2Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Jupiter Microtubule Associated Homolog 1 antibodyAnti-Androgen-Regulated Protein 2 antibodyAnti-Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed antibodyAnti-JPT1 antibodyAnti-ARM2 antibodyAnti-HN1 antibody |
Information sourced from Uniprot.org