Anti-JIK/TAOK3 antibody (Internal) (STJ70583)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-JIK/TAOK3 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 100kDa band observed in human Liver lysate (calculated MW of 105kDa according to NP_057365). Recommended concentration: 0.3-1.0 µg/ml.IHC: In paraffin embedded Human Prosta |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TAOK3 |
| Gene ID | 51347 |
| Uniprot ID | TAOK3_HUMAN |
| Accession Number | NP_057365.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | CHKKDHVFIRDEAGHGD |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2. |
| Function | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). |
| Protein Name | Serine/Threonine-Protein Kinase Tao3Cutaneous T-Cell Lymphoma-Associated Antigen Hd-Cl-09Ctcl-Associated Antigen Hd-Cl-09Dendritic Cell-Derived Protein KinaseJnk/Sapk-Inhibitory KinaseJun Kinase-Inhibitory KinaseKinase From Chicken Homolog AHkfc-AThousand And One Amino Acid Protein 3 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinAlso Localized To The Peripheral Cell Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao3 antibodyAnti-Cutaneous T-Cell Lymphoma-Associated Antigen Hd-Cl-09 antibodyAnti-Ctcl-Associated Antigen Hd-Cl-09 antibodyAnti-Dendritic Cell-Derived Protein Kinase antibodyAnti-Jnk/Sapk-Inhibitory Kinase antibodyAnti-Jun Kinase-Inhibitory Kinase antibodyAnti-Kinase From Chicken Homolog A antibodyAnti-Hkfc-A antibodyAnti-Thousand And One Amino Acid Protein 3 antibodyAnti-TAOK3 antibodyAnti-DPK antibodyAnti-JIK antibodyAnti-KDS antibodyAnti-MAP3K18 antibody |
Information sourced from Uniprot.org