Anti-JAML antibody [SAA1859] (STJA0020287)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Junctional Adhesion Molecule-Like antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1859 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | JAML |
| Gene ID | 120425 |
| Uniprot ID | JAML_HUMAN |
Additional Info
| Function | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. |
| Protein Name | Junctional Adhesion Molecule-LikeAdhesion Molecule Interacting With Cxadr Antigen 1Dendritic Cell-Specific Protein Crea7-1 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionLocalized At The Plasma Membrane And Enriched In Areas Of Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule-Like antibodyAnti-Adhesion Molecule Interacting With Cxadr Antigen 1 antibodyAnti-Dendritic Cell-Specific Protein Crea7-1 antibodyAnti-JAML antibodyAnti-AMICA1 antibodyAnti-UNQ722 antibodyAnti-PRO1387 antibody |
Information sourced from Uniprot.org