Anti-JADE1 antibody (STJA0007439)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PHF17
General Information
| Short Description | Rabbit polyclonal anti-Protein Jade-1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JADE1 |
| Gene ID | 79960 |
| Uniprot ID | JADE1_HUMAN |
| Immunogen | Synthesized peptide derived from human PHF17 |
| Specificity | This antibody detects endogenous levels of PHF17 at Human, Mouse |
Additional Info
| Function | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling.at least in part, cooperates with NPHP4 in this function. |
| Protein Name | Protein Jade-1Jade Family Phd Finger Protein 1Phd Finger Protein 17 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | NucleusChromosomeCytoplasmCytoskeletonCilium Basal BodyLocalizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Jade-1 antibodyAnti-Jade Family Phd Finger Protein 1 antibodyAnti-Phd Finger Protein 17 antibodyAnti-JADE1 antibodyAnti-KIAA1807 antibodyAnti-PHF17 antibody |
Information sourced from Uniprot.org