Anti-IYD antibody (STJA0007643)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human IYD
General Information
| Short Description | Rabbit polyclonal anti-Iodotyrosine deiodinase 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IYD |
| Gene ID | 389434 |
| Uniprot ID | IYD1_HUMAN |
| Immunogen | Synthesized peptide derived from human IYD |
| Specificity | This antibody detects endogenous levels of IYD at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine. |
| Protein Name | Iodotyrosine Deiodinase 1Iyd-1Iodotyrosine Dehalogenase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic Vesicle Membrane |
| Alternative Antibody Names | Anti-Iodotyrosine Deiodinase 1 antibodyAnti-Iyd-1 antibodyAnti-Iodotyrosine Dehalogenase 1 antibodyAnti-IYD antibodyAnti-C6orf71 antibodyAnti-DEHAL1 antibody |
Information sourced from Uniprot.org