Anti-ITPA antibody [R01-4D4] (STJA0034474)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Inosine triphosphate pyrophosphatase
General Information
| Short Description | Rabbit monoclonal anti-ITPA for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-4D4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ITPA |
| Gene ID | 3704 |
| Uniprot ID | ITPA_HUMAN |
| Immunogen | A synthetic peptide of human Inosine triphosphate pyrophosphatase |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. |
| Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
| Protein Name | Inosine Triphosphate PyrophosphataseItpaseInosine TriphosphataseNon-Canonical Purine Ntp PyrophosphataseNon-Standard Purine Ntp PyrophosphataseNucleoside-Triphosphate DiphosphataseNucleoside-Triphosphate PyrophosphataseNtpasePutative Oncogene Protein Hlc14-06-PXtp/Ditp Diphosphatase |
| Database Links | Reactome: R-HSA-74259Reactome: R-HSA-9755088 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Inosine Triphosphate Pyrophosphatase antibodyAnti-Itpase antibodyAnti-Inosine Triphosphatase antibodyAnti-Non-Canonical Purine Ntp Pyrophosphatase antibodyAnti-Non-Standard Purine Ntp Pyrophosphatase antibodyAnti-Nucleoside-Triphosphate Diphosphatase antibodyAnti-Nucleoside-Triphosphate Pyrophosphatase antibodyAnti-Ntpase antibodyAnti-Putative Oncogene Protein Hlc14-06-P antibodyAnti-Xtp/Ditp Diphosphatase antibodyAnti-ITPA antibodyAnti-C20orf37 antibodyAnti-My049 antibodyAnti-OK antibodyAnti-SW-cl.9 antibody |
Information sourced from Uniprot.org