• Western blot analysis of extracts of various cell lines, using ITGB8 antibody (STJ110731) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
  • Western blot analysis of various lysates, using ITGB8 antibody (STJ110731) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-ITGB8 antibody (43-320) (STJ110731)

SKU:
STJ110731

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ITGB8 (43-320) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ITGB8
Gene ID: 3696
Uniprot ID: ITB8_HUMAN
Immunogen Region: 43-320
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 43-320 of human ITGB8 (NP_002205.1).
Immunogen Sequence: EDNRCASSNAASCARCLALG PECGWCVQEDFISGGSRSER CDIVSNLISKGCSVDSIEYP SVHVIIPTENEINTQVTPGE VSIQLRPGAEANFMLKVHPL KKYPVDLYYLVDVSASMHNN IEKLNSVGNDLSRKMAFFSR DFRLGFGSYVDKTVSPYISI HPERIHNQCSDYNLDCMPPH GYIHVLSLTENITEFEKAVH RQKISGNIDTPEGGFDAMLQ AAVCESHIGWRKEAKRLLL
Tissue Specificity Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
Function Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis.
Protein Name Integrin Beta-8
Database Links Reactome: R-HSA-2129379
Reactome: R-HSA-216083
Reactome: R-HSA-2173789
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Beta-8 antibody
Anti-ITGB8 antibody

Information sourced from Uniprot.org

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