Anti-ITGAM antibody (280-360 aa) (STJ98736)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 280-360
General Information
| Short Description | Rabbit polyclonal anti-Integrin alpha-M (280-360 aa) for use in IHC, IF, IHC and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ITGAM |
| Gene ID | 3684 |
| Uniprot ID | ITAM_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 280-360 |
| Immunogen Region | 280-360 aa |
| Specificity | The antibody detects endogenous CD11b |
Additional Info
| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Protein Name | Integrin Alpha-MCd11 Antigen-Like Family Member BCr-3 Alpha ChainCell Surface Glycoprotein Mac-1 Subunit AlphaLeukocyte Adhesion Receptor Mo1Neutrophil Adherence ReceptorCd Antigen Cd11b |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-6785807Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-Integrin Alpha-M antibodyAnti-Cd11 Antigen-Like Family Member B antibodyAnti-Cr-3 Alpha Chain antibodyAnti-Cell Surface Glycoprotein Mac-1 Subunit Alpha antibodyAnti-Leukocyte Adhesion Receptor Mo1 antibodyAnti-Neutrophil Adherence Receptor antibodyAnti-Cd Antigen Cd11b antibodyAnti-ITGAM antibodyAnti-CD11B antibodyAnti-CR3A antibody |
Information sourced from Uniprot.org