| Host: |
Mouse |
| Applications: |
WB/ICC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Integrin Alpha L (Extracellular region) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M594 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:1000ICC 1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITGAL |
| Gene ID: |
3683 |
| Uniprot ID: |
ITAL_HUMAN |
| Immunogen Region: |
Extracellular region |
| Specificity: |
The antibody detects a 180 kDa* protein corresponding to the molecular mass of Integrin Alpha L on SDS-PAGE immunoblots of human Jurkat cells. |
| Immunogen: |
Clone M594 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin Alpha L. This sequence has low homology to other integrin family members. |
| Tissue Specificity | Leukocytes. |
| Post Translational Modifications | In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents. |
| Function | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. |
| Protein Name | Integrin Alpha-LCd11 Antigen-Like Family Member ALeukocyte Adhesion Glycoprotein Lfa-1 Alpha ChainLfa-1aLeukocyte Function-Associated Molecule 1 Alpha ChainCd Antigen Cd11a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-6798695Reactome: R-HSA-8949275 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinUpon Antigen Recognition By The TcrIs Recruited To Lipid Rafts |
| Alternative Antibody Names | Anti-Integrin Alpha-L antibodyAnti-Cd11 Antigen-Like Family Member A antibodyAnti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibodyAnti-Lfa-1a antibodyAnti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibodyAnti-Cd Antigen Cd11a antibodyAnti-ITGAL antibodyAnti-CD11A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
