Anti-ISY1 antibody (1-307) (STJ115770)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ISY1 (1-307) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ISY1 |
| Gene ID | 100534599/57461 |
| Uniprot ID | ISY1_HUMAN |
| Immunogen Region | 1-307 |
| Immunogen Sequence | MARNAEKAMTALARFRQAQL EEGKVKERRPFLASECTELP KAEKWRRQIIGEISKKVAQI QNAGLGEFRIRDLNDEINKL LREKGHWEVRIKELGGPDYG KVGPKMLDHEGKEVPGNRGY KYFGAAKDLPGVRELFEKER QVRWLMPVIPALWEAEAGGS QALPPPRKTRAELMKAIDFE YYGYLDEDDGVIVPLEQEYE KKLRAELVEKWKAEREARLA RGEKEEEEEEEEEINIYAV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human ISY1 (NP_001186398.1). |
Additional Info
| Function | Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state. Involved in pre-mRNA splicing as component of the spliceosome. |
| Protein Name | Pre-Mrna-Splicing Factor Isy1 Homolog |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Isy1 Homolog antibodyAnti-ISY1 antibodyAnti-KIAA1160 antibody |
Information sourced from Uniprot.org