![Anti-Isocitrate Dehydrogenenase 1 IDH1-R132S antibody [SMab-1] (STJ16101370)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/151879/346964/STJ16101370_1__82391.1681999195.jpg?c=1 "Anti-Isocitrate Dehydrogenenase 1 IDH1-R132S antibody [SMab-1] (STJ16101370)")
![Anti-Isocitrate Dehydrogenenase 1 IDH1-R132S antibody [SMab-1] (STJ16101370)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/151879/346964/STJ16101370_1__82391.1681999195.jpg?c=1 "Anti-Isocitrate Dehydrogenenase 1 IDH1-R132S antibody [SMab-1] (STJ16101370)")
Anti-Isocitrate Dehydrogenenase 1 IDH1-R132S antibody [SMab-1] (STJ16101370)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenKLH-conjugated peptide human IDH1-R132S
General Information
| Short Description | Mouse monoclonal anti-Isocitrate Dehydrogenenase 1 IDH1-R132S for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SMab-1 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Dilution Range | IHC-P 1:25-1:50 |
| Formulation | Tissue culture supernatant with sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | KLH-conjugated peptide human IDH1-R132S |
Additional Info
| Background | Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADPdependent enzyme, which catalyzes the decarboxylation of isocitrate into Alpha-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R (-)-2-hydroxyglutarate. |
Information sourced from Uniprot.org