Anti-ISG20 antibody (1-70) (STJ116944)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ISG20 (1-70) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ISG20 |
| Gene ID | 3669 |
| Uniprot ID | ISG20_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MAGSREVVAMDCEMVGLGPH RESGLARCSLVNVHGAVLYD KFIRPEGEITDYRTRVSGVT PQHMVGATPF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ISG20 (NP_002192.2). |
Additional Info
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines. |
| Function | Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins. Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies. May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition. May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. |
| Protein Name | Interferon-Stimulated Gene 20 Kda ProteinEstrogen-Regulated Transcript 45 ProteinPromyelocytic Leukemia Nuclear Body-Associated Protein Isg20 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | NucleusNucleolusCytoplasmCajal BodyP-Body |
| Alternative Antibody Names | Anti-Interferon-Stimulated Gene 20 Kda Protein antibodyAnti-Estrogen-Regulated Transcript 45 Protein antibodyAnti-Promyelocytic Leukemia Nuclear Body-Associated Protein Isg20 antibodyAnti-ISG20 antibodyAnti-HEM45 antibody |
Information sourced from Uniprot.org