Anti-IRS4 antibody (STJA0004313)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human IRS4
General Information
| Short Description | Rabbit polyclonal anti-Insulin Receptor Substrate 4 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.02 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IRS4 |
| Gene ID | 8471 |
| Uniprot ID | IRS4_HUMAN |
| Immunogen | Synthetic peptide of human IRS4 |
Additional Info
| Tissue Specificity | Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction. Ubiquitinated in a ASB4-dependent manner, leading to proteasomal degradation. |
| Function | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. |
| Protein Name | Insulin Receptor Substrate 4Irs-4160 Kda Phosphotyrosine ProteinPy160Phosphoprotein Of 160 KdaPp160 |
| Database Links | Reactome: R-HSA-2428928 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Insulin Receptor Substrate 4 antibodyAnti-Irs-4 antibodyAnti-160 Kda Phosphotyrosine Protein antibodyAnti-Py160 antibodyAnti-Phosphoprotein Of 160 Kda antibodyAnti-Pp160 antibodyAnti-IRS4 antibody |
Information sourced from Uniprot.org