Anti-IRF9 antibody (STJA0006896)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human IRF9
General Information
| Short Description | Rabbit polyclonal anti-Interferon regulatory factor 9 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IRF9 |
| Gene ID | 10379 |
| Uniprot ID | IRF9_HUMAN |
| Immunogen | Synthesized peptide derived from human IRF9 |
| Specificity | This antibody detects endogenous levels of IRF9 at Human, Mouse |
Additional Info
| Function | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
| Protein Name | Interferon Regulatory Factor 9Irf-9Ifn-Alpha-Responsive Transcription Factor SubunitIsgf3 P48 SubunitInterferon-Stimulated Gene Factor 3 GammaIsgf-3 GammaTranscriptional Regulator Isgf3 Subunit Gamma |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmNucleusTranslocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 9 antibodyAnti-Irf-9 antibodyAnti-Ifn-Alpha-Responsive Transcription Factor Subunit antibodyAnti-Isgf3 P48 Subunit antibodyAnti-Interferon-Stimulated Gene Factor 3 Gamma antibodyAnti-Isgf-3 Gamma antibodyAnti-Transcriptional Regulator Isgf3 Subunit Gamma antibodyAnti-IRF9 antibodyAnti-ISGF3G antibody |
Information sourced from Uniprot.org