Anti-IRF4 antibody (350-451 aa) [ABT080] (STJ197173)

Name: Anti-IRF4 antibody (350-451 aa) [ABT080] (STJ197173)
SKU: STJ197173
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostMouse

ConjugationUnconjugated

IsotypeIgG1k

ImmunogenSynthesized peptide derived from the human MUM1 at the amino acid range 350-451

STJ197173

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Short Description	Mouse monoclonal anti-Interferon regulatory factor 4 (350-451 aa) for use in IHC, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	IHC/WB/IF
Host	Mouse
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	ABT080
Isotype	IgG1k
Conjugation	Unconjugated
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range	IHC-P 1:100-500 WB 1:200-1000 IF 1:100-500
Formulation	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	IRF4
Gene ID	3662
Uniprot ID	IRF4_HUMAN
Immunogen	Synthesized peptide derived from the human MUM1 at the amino acid range 350-451
Immunogen Region	350-451 aa
Specificity	The antibody can specifically recognize human MUM1 protein.

Post Translational Modifications	Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.
Function	Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
Protein Name	Interferon Regulatory Factor 4 Irf-4 Lymphocyte-Specific Interferon Regulatory Factor Lsirf Multiple Myeloma Oncogene 1 Nf-Em5
Database Links	Reactome: R-HSA-6785807 Reactome: R-HSA-877300 Reactome: R-HSA-909733 Reactome: R-HSA-9725371 Reactome: R-HSA-9824585
Cellular Localisation	Nucleus Cytoplasm
Alternative Antibody Names	Anti-Interferon Regulatory Factor 4 antibody Anti-Irf-4 antibody Anti-Lymphocyte-Specific Interferon Regulatory Factor antibody Anti-Lsirf antibody Anti-Multiple Myeloma Oncogene 1 antibody Anti-Nf-Em5 antibody Anti-IRF4 antibody Anti-MUM1 antibody

Information sourced from Uniprot.org