| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IRAK3 (367-596) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IRAK3 |
| Gene ID: |
11213 |
| Uniprot ID: |
IRAK3_HUMAN |
| Immunogen Region: |
367-596 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 367-596 of human IRAK3 (NP_009130.2). |
| Immunogen Sequence: |
VLTGCRVVLDDPKHIQLRDL LRELMEKRGLDSCLSFLDKK VPPCPRNFSAKLFCLAGRCA ATRAKLRPSMDEVLNTLEST QASLYFAEDPPTSLKSFRCP SPLFLENVPSIPVEDDESQN NNLLPSDEGLRIDRMTQKTP FECSQSEVMFLSLDKKPESK RNEEACNMPSSSCEESWFPK YIVPSQDLRPYKVNIDPSSE APGHSCRSRPVESSCSSKFS WDEYEQYKKE |
| Tissue Specificity | Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes. |
| Function | Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. |
| Protein Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-MInactive Il-1 Receptor-Associated Kinase 3 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9020702 |
| Cellular Localisation | CytoplasmNucleusIn Dendritic CellsTranslocates Into The Nucleus Upon Il33 Stimulation |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Associated Kinase 3 antibodyAnti-Irak-3 antibodyAnti-Il-1 Receptor-Associated Kinase M antibodyAnti-Irak-M antibodyAnti-Inactive Il-1 Receptor-Associated Kinase 3 antibodyAnti-IRAK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
