Anti-IRAK2 antibody (50-250) [S5MR] (STJ11102125)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal IRAK2 (50-250) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IRAK2 |
| Gene ID | 3656 |
| Uniprot ID | IRAK2_HUMAN |
| Immunogen Region | 50-250 |
| Immunogen Sequence | RVQGVSITRELLWWWGMRQA TVQQLVDLLCRLELYRAAQI ILNWKPAPEIRCPIPAFPDS VKPEKPLAASVRKAEDEQEE GQPVRMATFPGPGSSPARAH QPAFLQPPEEDAPHSLRSDL PTSSDSKDFSTSIPKQEKLL SLAGDSLFWSEADVVQATDD FNQNRKISQGTFADVYRGHR HGKPFVFKKLRETACSSPGS I |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-250 of human IRAK2 (O43187). |
Additional Info
| Tissue Specificity | Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. |
| Function | Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. |
| Protein Name | Interleukin-1 Receptor-Associated Kinase-Like 2Irak-2 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-168638Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-9020702Reactome: R-HSA-937042Reactome: R-HSA-937072Reactome: R-HSA-9692916Reactome: R-HSA-9705671Reactome: R-HSA-975138Reactome: R-HSA-975155Reactome: R-HSA-975163Reactome: R-HSA-975871 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Associated Kinase-Like 2 antibodyAnti-Irak-2 antibodyAnti-IRAK2 antibody |
Information sourced from Uniprot.org