| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IPO5 (20-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IPO5 |
| Gene ID: |
3843 |
| Uniprot ID: |
IPO5_HUMAN |
| Immunogen Region: |
20-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human IPO5 (NP_002262.3). |
| Immunogen Sequence: |
AAAAAEQQQFYLLLGNLLSP DNVVRKQAEETYENIPGQSK ITFLLQAIRNTTAAEEARQM AAVLLRRLLSSAFDEVYPAL PSDVQTAIKSELLMIIQMET QSSMRKKVCDIAAELARNLI DEDGNNQWPEGLKFLFDSVS SQNVGLREAALHIFWNFPGI FGNQQQHYLDVIKRMLVQCM QDQEHPSIRTLSARATAAFI LANEHNVALFKHFADLLPGF LQAVNDSCYQNDDSVLKSL |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. |
| Protein Name | Importin-5Imp5Importin Subunit Beta-3Karyopherin Beta-3Ran-Binding Protein 5Ranbp5 |
| Database Links | Reactome: R-HSA-192905 |
| Cellular Localisation | CytoplasmNucleusNucleolusNuclear RimFound Particularly In The Nuclear Rim And Nucleolus |
| Alternative Antibody Names | Anti-Importin-5 antibodyAnti-Imp5 antibodyAnti-Importin Subunit Beta-3 antibodyAnti-Karyopherin Beta-3 antibodyAnti-Ran-Binding Protein 5 antibodyAnti-Ranbp5 antibodyAnti-IPO5 antibodyAnti-KPNB3 antibodyAnti-RANBP5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
