• Western blot analysis of lysates from HT-29 and COS7 cells, using IPMK Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using IPMK Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-IPMK antibody (311-360 aa) (STJ93749)

SKU:
STJ93749

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Inositol polyphosphate multikinase (311-360 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IPMK
Gene ID: 253430
Uniprot ID: IPMK_HUMAN
Immunogen Region: 311-360 aa
Specificity: IPMK Polyclonal Antibody detects endogenous levels of IPMK protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human IPMK at the amino acid range 311-360
Function Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6).
Protein Name Inositol Polyphosphate Multikinase
Inositol 1 -3 -4 -6-Tetrakisphosphate 5-Kinase
Database Links Reactome: R-HSA-1855191
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Inositol Polyphosphate Multikinase antibody
Anti-Inositol 1 -3 -4 -6-Tetrakisphosphate 5-Kinase antibody
Anti-IPMK antibody
Anti-IMPK antibody

Information sourced from Uniprot.org

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