Anti-Ionized calcium-binding adapter molecule 1 antibody (C-Term) (STJA0040990)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenC-terminal peptide of human IBA1 protein coupled to KLH.
General Information
| Short Description | Rabbit polyclonal anti-Ionized calcium-binding adapter molecule 1 (C-Term) for use in ICC, IHC-F and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC-F/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | WB 1:1000-1:5000IHC 1:2000-1:5000ICC 1:1000-1:5000 |
| Formulation | Lyophilized with sodium azide. |
| Storage Instruction | Spin vial briefly before opening. Reconstitute with 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at-20°C for long-term s |
Target Information
| Gene Symbol | AIF1 |
| Gene ID | 199 |
| Uniprot ID | AIF1_HUMAN |
| Immunogen | C-terminal peptide of human IBA1 protein coupled to KLH. |
| Immunogen Region | C-Term |
| Immunogen Sequence | Human |
| Specificity | Human, reacts with human, rat, mouse. |
Additional Info
| Tissue Specificity | Detected in T-lymphocytes and peripheral blood mononuclear cells. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Protein Name | Allograft Inflammatory Factor 1Aif-1Ionized Calcium-Binding Adapter Molecule 1Protein G1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePhagocytic CupAssociated With The Actin Cytoskeleton At Membrane Ruffles And At Sites Of Phagocytosis |
| Alternative Antibody Names | Anti-Allograft Inflammatory Factor 1 antibodyAnti-Aif-1 antibodyAnti-Ionized Calcium-Binding Adapter Molecule 1 antibodyAnti-Protein G1 antibodyAnti-AIF1 antibodyAnti-G1 antibodyAnti-IBA1 antibody |
Information sourced from Uniprot.org