Anti-Involucrin antibody (100-200) [S2MR] (STJ11102752)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Involucrin (100-200) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IVL |
| Gene ID | 3713 |
| Uniprot ID | INVO_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | KAENPEQQLKQEKTQRDQQL NKQLEEEKKLLDQQLDQELV KRDEQLGMKKEQLLELPEQQ EGHLKHLEQQEGQLKHPEQQ EGQLELPEQQEGQLELPEQQ E |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Involucrin (P07476). |
Additional Info
| Tissue Specificity | Keratinocytes of epidermis and other stratified squamous epithelia. |
| Post Translational Modifications | Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide. |
| Function | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
| Protein Name | Involucrin |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmConstituent Of The Scaffolding Of The Cornified Envelope |
| Alternative Antibody Names | Anti-Involucrin antibodyAnti-IVL antibody |
Information sourced from Uniprot.org