| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Integrator complex subunit 6 (550-630 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | INTS6 |
| Gene ID: | 26512 |
| Uniprot ID: | INT6_HUMAN |
| Immunogen Region: | 550-630 aa |
| Specificity: | INT6 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 550-630 |
| Function | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role.an ectopic expression suppressing tumor cell growth. |
| Protein Name | Integrator Complex Subunit 6 Int6 Dbi-1 Protein Ddx26 Protein Deleted In Cancer 1 Dice1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 6 antibody Anti-Int6 antibody Anti-Dbi-1 antibody Anti-Protein Ddx26 antibody Anti-Protein Deleted In Cancer 1 antibody Anti-Dice1 antibody Anti-INTS6 antibody Anti-DBI1 antibody Anti-DDX26 antibody Anti-DDX26A antibody |
Information sourced from Uniprot.org