Anti-INTS11 antibody (331-600 aa) [S4922RM] (STJ11104922)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Integrator Complex Subunit 11 (331-600 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4922RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:7000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INTS11 |
| Gene ID | 54973 |
| Uniprot ID | INT11_HUMAN |
| Immunogen Region | 331-600 aa |
| Immunogen Sequence | GQSLQIFRKWAGNEKNMVIM PGYCVQGTVGHKILSGQRKL EMEGRQVLEVKMQVEYMSFS AHADAKGIMQLVGQAEPESV LLVHGEAKKMEFLKQKIEQE LRVNCYMPANGETVTLPTSP SIPVGISLGLLKREMAQGLL PEAKKPRLLHGTLIMKDSNF RLVSSEQALKELGLAEHQLR FTCRVHLHDTRKEQETALRV YSHLKSVLKDHCVQHLPDGS VTVESVLLQAAAPSEDPGT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 331-600 of human INTS11. (NP_060341.2). |
Additional Info
| Post Translational Modifications | Sumoylated.sumoylation regulates its subcellular location and is required for integrator complex integrity. |
| Function | RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. |
| Protein Name | Integrator Complex Subunit 11Int11Cleavage And Polyadenylation-Specific Factor 3-Like ProteinCpsf3-Like ProteinProtein Related To Cpsf Subunits Of 68 KdaRc-68 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 11 antibodyAnti-Int11 antibodyAnti-Cleavage And Polyadenylation-Specific Factor 3-Like Protein antibodyAnti-Cpsf3-Like Protein antibodyAnti-Protein Related To Cpsf Subunits Of 68 Kda antibodyAnti-Rc-68 antibodyAnti-INTS11 antibodyAnti-CPSF3L antibodyAnti-RC68 antibody |
Information sourced from Uniprot.org