Anti-Interleukin-10 antibody (STJ16101143)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	Ig
Formulation:	PBS with 0.1% BSA and 0.02% sodium azide
Purification:	Affinity purified
Concentration:	100 ug/mL
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	IL10
Gene ID:	3586
Uniprot ID:	IL10_HUMAN

Tissue Specificity	Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
Function	Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
Protein Name	Interleukin-10 Il-10 Cytokine Synthesis Inhibitory Factor Csif
Database Links	Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-8950505 Reactome: R-HSA-9662834 Reactome: R-HSA-9664323
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Interleukin-10 antibody Anti-Il-10 antibody Anti-Cytokine Synthesis Inhibitory Factor antibody Anti-Csif antibody Anti-IL10 antibody

Information sourced from Uniprot.org

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