| Tissue Specificity | Lymphoid cells. |
| Post Translational Modifications | Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. |
| Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. |
| Protein Name | Interferon Regulatory Factor 4Irf-4Lymphocyte-Specific Interferon Regulatory FactorLsirfMultiple Myeloma Oncogene 1Nf-Em5 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-909733Reactome: R-HSA-9725371Reactome: R-HSA-9824585 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 4 antibodyAnti-Irf-4 antibodyAnti-Lymphocyte-Specific Interferon Regulatory Factor antibodyAnti-Lsirf antibodyAnti-Multiple Myeloma Oncogene 1 antibodyAnti-Nf-Em5 antibodyAnti-IRF4 antibodyAnti-MUM1 antibody |
Information sourced from Uniprot.org
