Anti-INSRR antibody (747-921) (STJ112123)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal INSRR (747-921) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INSRR |
| Gene ID | 3645 |
| Uniprot ID | INSRR_HUMAN |
| Immunogen Region | 747-921 |
| Immunogen Sequence | AAGPLRLGGNSSDFEIQEDK VPRERAVLSGLRHFTEYRID IHACNHAAHTVGCSAATFVF ARTMPHREADGIPGKVAWEA SSKNSVLLRWLEPPDPNGLI LKYEIKYRRLGEEATVLCVS RLRYAKFGGVHLALLPPGNY SARVRATSLAGNGSWTDSVA FYILGPEEEDAGGLH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1). |
Additional Info
| Post Translational Modifications | Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5. |
| Function | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
| Protein Name | Insulin Receptor-Related ProteinIrrIr-Related Receptor Cleaved Into - Insulin Receptor-Related Protein Alpha Chain - Insulin Receptor-Related Protein Beta Chain |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Insulin Receptor-Related Protein antibodyAnti-Irr antibodyAnti-Ir-Related Receptor Cleaved Into - Insulin Receptor-Related Protein Alpha Chain - Insulin Receptor-Related Protein Beta Chain antibodyAnti-INSRR antibodyAnti-IRR antibody |
Information sourced from Uniprot.org