Anti-INPP5F antibody (1006-1056 aa) (STJ195505)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SAC2 at the amino acid range 1006-1056
General Information
| Short Description | Rabbit polyclonal anti-Phosphatidylinositide phosphatase SAC2 (1006-1056 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INPP5F |
| Gene ID | 22876 |
| Uniprot ID | SAC2_HUMAN |
| Immunogen | Synthesized peptide derived from the human SAC2 at the amino acid range 1006-1056 |
| Immunogen Region | 1006-1056 aa |
| Specificity | This antibody detects endogenous levels of SAC2 at Human/Mouse |
Additional Info
| Function | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries. |
| Protein Name | Phosphatidylinositide Phosphatase Sac2Inositol Polyphosphate 5-Phosphatase FSac Domain-Containing Inositol Phosphatase 2Sac Domain-Containing Phosphoinositide 4-Phosphatase 2Hsac2 |
| Database Links | Reactome: R-HSA-1660516 |
| Cellular Localisation | MembraneClathrin-Coated PitEarly EndosomeRecycling EndosomeAlso Found On Macropinosomes |
| Alternative Antibody Names | Anti-Phosphatidylinositide Phosphatase Sac2 antibodyAnti-Inositol Polyphosphate 5-Phosphatase F antibodyAnti-Sac Domain-Containing Inositol Phosphatase 2 antibodyAnti-Sac Domain-Containing Phosphoinositide 4-Phosphatase 2 antibodyAnti-Hsac2 antibodyAnti-INPP5F antibodyAnti-KIAA0966 antibodyAnti-SAC2 antibodyAnti-MSTP007 antibodyAnti-MSTP047 antibody |
Information sourced from Uniprot.org