Anti-INPP5B antibody (292-342 aa) (STJ195512)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human I5P2 at the amino acid range 292-342
General Information
| Short Description | Rabbit polyclonal anti-Type II inositol 1, 4, 5-trisphosphate 5-phosphatase (292-342 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INPP5B |
| Gene ID | 3633 |
| Uniprot ID | I5P2_HUMAN |
| Immunogen | Synthesized peptide derived from the human I5P2 at the amino acid range 292-342 |
| Immunogen Region | 292-342 aa |
| Specificity | This antibody detects endogenous levels of I5P2 at Human/Mouse |
Additional Info
| Post Translational Modifications | Isoprenylation at Cys-990 may be required for localization at the membrane. May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form. |
| Function | Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. |
| Protein Name | Type Ii Inositol 1 -4 -5-Trisphosphate 5-Phosphatase75 Kda Inositol Polyphosphate-5-PhosphatasePhosphoinositide 5-Phosphatase5ptase |
| Database Links | Reactome: R-HSA-1855183Reactome: R-HSA-1855204 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum-Golgi Intermediate CompartmentEarly Endosome MembraneMembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesiclePhagosome MembraneGolgi Apparatus |
| Alternative Antibody Names | Anti-Type Ii Inositol 1 -4 -5-Trisphosphate 5-Phosphatase antibodyAnti-75 Kda Inositol Polyphosphate-5-Phosphatase antibodyAnti-Phosphoinositide 5-Phosphatase antibodyAnti-5ptase antibodyAnti-INPP5B antibodyAnti-OCRL2 antibody |
Information sourced from Uniprot.org