Anti-INPP5A antibody (10-200) (STJ26233)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal INPP5A (10-200) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INPP5A |
| Gene ID | 3632 |
| Uniprot ID | I5P1_HUMAN |
| Immunogen Region | 10-200 |
| Immunogen Sequence | TAVLLVTANVGSLFDDPENL QKNWLREFYQVVHTHKPHFM ALHCQEFGGKNYEASMSHVD KFVKELLSSDAMKEYNRARV YLDENYKSQEHFTALGSFYF LHESLKNIYQFDFKAKKYRK VAGKEIYSDTLESTPMLEKE KFPQDYFPECKWSRKGFIRT RWCIADCAFDLVNIHLFHDA SNLVAWETSPS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 10-200 of human INPP5A (NP_005530.3). |
Additional Info
| Tissue Specificity | Predominantly expressed in heart, brain, and skeletal muscle. In brain.high level in Purkinje cells. |
| Post Translational Modifications | Isoprenylation at Cys-409 is required for localization at the membrane. |
| Function | Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells. |
| Protein Name | Inositol Polyphosphate-5-Phosphatase A43 Kda Inositol Polyphosphate 5-PhosphataseType I Inositol 1 -4 -5-Trisphosphate 5-Phosphatase5ptase |
| Database Links | Reactome: R-HSA-1855183 |
| Cellular Localisation | Cell MembraneLipid-AnchorCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Inositol Polyphosphate-5-Phosphatase A antibodyAnti-43 Kda Inositol Polyphosphate 5-Phosphatase antibodyAnti-Type I Inositol 1 -4 -5-Trisphosphate 5-Phosphatase antibodyAnti-5ptase antibodyAnti-INPP5A antibodyAnti-5PTASE antibody |
Information sourced from Uniprot.org