Anti-INPP4B antibody (380-600) (STJ118889)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal INPP4B (380-600) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INPP4B |
| Gene ID | 8821 |
| Uniprot ID | INP4B_HUMAN |
| Immunogen Region | 380-600 |
| Immunogen Sequence | GLRKLLHRFETERRNTGYQF IYYSPENTAKAKEVLSNINQ LQPLIATHADLLLNSASQHS PDSLKNSLKMLSEKTELFVH AFKDQLVRSALLALYTARPG GILKKPPSPKSSTEESSPQD QPPVMRGQDSIPHHSDYDEE EWDRVWANVGKSLNCIIAMV DKLIERDGGSEGSGGNNDGE KEPSLTDAIPSHPREDWYEQ LYPLILTLKDCMGEVVNRAK Q |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 380-600 of human INPP4B (NP_003857.2). |
Additional Info
| Tissue Specificity | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. |
| Protein Name | Inositol Polyphosphate 4-Phosphatase Type IiType Ii Inositol 3 -4-Bisphosphate 4-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1855183 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 4-Phosphatase Type Ii antibodyAnti-Type Ii Inositol 3 -4-Bisphosphate 4-Phosphatase antibodyAnti-INPP4B antibody |
Information sourced from Uniprot.org