Anti-INPP4A antibody (1-250) (STJ110004)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal INPP4A (1-250) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | INPP4A |
| Gene ID | 3631 |
| Uniprot ID | INP4A_HUMAN |
| Immunogen Region | 1-250 |
| Immunogen Sequence | MTAREHSPRHGARARAMQRA STIDVAADMLGLSLAGNIQD PDEPILEFSLACSELHTPSL DRKPNSFVAVSVTTPPQAFW TKHAQTEIIEGTNNPIFLSS IAFFQDSLINQMTQVKLSVY DVKDRSQGTMYLLGSGTFIV KDLLQDRHHRLHLTLRSAES DRVGNITVIGWQMEEKSDQR PPVTRSVDTVNGRMVLPVDE SLTEALGIRSKYASLRKDTL LKSVFGGAICRMYRFPTTD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human INPP4A (NP_004018.1). |
Additional Info
| Tissue Specificity | Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. |
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current. Isoform 4: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. |
| Protein Name | Inositol Polyphosphate-4-Phosphatase Type I AInositol Polyphosphate 4-Phosphatase Type IType I Inositol 3 -4-Bisphosphate 4-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1855183 |
| Cellular Localisation | Early Endosome MembraneRecycling Endosome MembraneCell MembraneNucleusCytoplasmPostsynaptic DensityTranslocates To The Plasma Membrane Upon Egf StimulationShuttles Between The Cytoplasm And The NucleusDepending On The Cell Cycle StageWith Highest Amounts Detected In The Nucleus During The G0/G1phase |
| Alternative Antibody Names | Anti-Inositol Polyphosphate-4-Phosphatase Type I A antibodyAnti-Inositol Polyphosphate 4-Phosphatase Type I antibodyAnti-Type I Inositol 3 -4-Bisphosphate 4-Phosphatase antibodyAnti-INPP4A antibody |
Information sourced from Uniprot.org