Anti-INO80 antibody (Internal) (STJ72061)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-INO80 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments in Human Brain (Cerebellum) and Human Testis lysates and in lysates of cell lines HeLa and K562 gave no specific signal but low background (at antibody concentra |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | INO80 |
| Gene ID | 54617 |
| Uniprot ID | INO80_HUMAN |
| Accession Number | NP_060023.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TQEDYDSNHFKAQ |
Additional Info
| Function | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle. |
| Protein Name | Chromatin-Remodeling Atpase Ino80Hino80Dna Helicase-Related Ino80 Complex Homolog 1Dna Helicase-Related Protein Ino80Ino80 Complex Subunit A |
| Database Links | Reactome: R-HSA-5689603Reactome: R-HSA-5696394 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonSpindleChromosomeLocalizes To The Cytoplasm In Quiescent CellAssociates With Spindle Microtubules During MitosisColocalizes With Pcna At Replication Forks During S-PhaseRecruited To Dna Damage Sites In A Actr8-Dependent Manner |
| Alternative Antibody Names | Anti-Chromatin-Remodeling Atpase Ino80 antibodyAnti-Hino80 antibodyAnti-Dna Helicase-Related Ino80 Complex Homolog 1 antibodyAnti-Dna Helicase-Related Protein Ino80 antibodyAnti-Ino80 Complex Subunit A antibodyAnti-INO80 antibodyAnti-INO80A antibodyAnti-INOC1 antibodyAnti-KIAA1259 antibody |
Information sourced from Uniprot.org