Anti-ING5 antibody (1-220) (STJ29427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ING5 (1-220) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ING5 |
| Gene ID | 84289 |
| Uniprot ID | ING5_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MATAMYLEHYLDSIENLPCE LQRNFQLMRELDQRTEDKKA EIDILAAEYISTVKTLSPDQ RVERLQKIQNAYSKCKEYSD DKVQLAMQTYEMVDKHIRRL DADLARFEADLKDKMEGSDF ESSGGRGLKKGRGQKEKRGS RGRGRRTSEEDTPKKKKHKG GSEFTDTILSVHPSDVLDMP VDPNEPTYCLCHQVSYGEMI GCDNPDCPIEWFHFACVDLT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ING5 (NP_115705.2). |
Additional Info
| Tissue Specificity | Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells. |
| Function | Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner. |
| Protein Name | Inhibitor Of Growth Protein 5P28ing5 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-6804758 |
| Cellular Localisation | NucleusChromosomeLocalizes To Transcription Start Sites |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 5 antibodyAnti-P28ing5 antibodyAnti-ING5 antibody |
Information sourced from Uniprot.org