Anti-ING2 antibody (1-280aa) [AT39E5] (STJA0041680)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1bk
ImmunogenRecombinant human ING2 (1-280aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-ING2 (1-280aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT39E5 |
| Isotype | IgG1bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ING2 |
| Gene ID | 3622 |
| Uniprot ID | ING2_HUMAN |
| Accession Number | NP_001555 |
| Immunogen | Recombinant human ING2 (1-280aa) purified from E. coli |
| Immunogen Region | 1-280aa |
Additional Info
| Tissue Specificity | Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues. |
| Post Translational Modifications | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
| Protein Name | Inhibitor Of Growth Protein 2Inhibitor Of Growth 1-Like ProteinIng1lpP32P33ing2 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-6811555 |
| Cellular Localisation | NucleusPredominantly NuclearLocalized To Chromatin And Nuclear MatrixUpon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin AndAt Least PartiallyTranslocated To The Cytoplasm |
| Alternative Antibody Names | Anti-Inhibitor Of Growth Protein 2 antibodyAnti-Inhibitor Of Growth 1-Like Protein antibodyAnti-Ing1lp antibodyAnti-P32 antibodyAnti-P33ing2 antibodyAnti-ING2 antibodyAnti-ING1L antibody |
Information sourced from Uniprot.org