Anti-INDO/IDO antibody (Internal) (STJ70786)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-INDO/IDO (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.IHC: Paraffin embedded Human Placenta. Recommended concentration: 4-6µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | IDO1 |
| Gene ID | 3620 |
| Uniprot ID | I23O1_HUMAN |
| Accession Number | NP_002155.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | CVLANWKKKDPNK |
Additional Info
| Function | Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection. |
| Protein Name | Indoleamine 2 -3-Dioxygenase 1Ido-1Indoleamine-Pyrrole 2 -3-Dioxygenase |
| Database Links | Reactome: R-HSA-71240 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Indoleamine 2 -3-Dioxygenase 1 antibodyAnti-Ido-1 antibodyAnti-Indoleamine-Pyrrole 2 -3-Dioxygenase antibodyAnti-IDO1 antibodyAnti-IDO antibodyAnti-INDO antibody |
Information sourced from Uniprot.org