Anti-IMPDH2 antibody (215-514) (STJ118074)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IMPDH2 (215-514) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IMPDH2 |
| Gene ID | 3615 |
| Uniprot ID | IMDH2_HUMAN |
| Immunogen Region | 215-514 |
| Immunogen Sequence | DDELVAIIARTDLKKNRDYP LASKDAKKQLLCGAAIGTHE DDKYRLDLLAQAGVDVVVLD SSQGNSIFQINMIKYIKDKY PNLQVIGGNVVTAAQAKNLI DAGVDALRVGMGSGSICITQ EVLACGRPQATAVYKVSEYA RRFGVPVIADGGIQNVGHIA KALALGASTVMMGSLLAATT EAPGEYFFSDGIRLKKYRGM GSLDAMDKHLSSQNRYFSEA DKIKVAQGVSGAVQDKGSI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2). |
Additional Info
| Tissue Specificity | IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor. |
| Post Translational Modifications | Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 2Imp Dehydrogenase 2Impd 2Impdh 2Inosine-5'-Monophosphate Dehydrogenase Type IiImp Dehydrogenase IiImpdh-Ii |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-73817Reactome: R-HSA-9679191Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmNucleusCytosolCan Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion |
| Alternative Antibody Names | Anti-Inosine-5'-Monophosphate Dehydrogenase 2 antibodyAnti-Imp Dehydrogenase 2 antibodyAnti-Impd 2 antibodyAnti-Impdh 2 antibodyAnti-Inosine-5'-Monophosphate Dehydrogenase Type Ii antibodyAnti-Imp Dehydrogenase Ii antibodyAnti-Impdh-Ii antibodyAnti-IMPDH2 antibodyAnti-IMPD2 antibody |
Information sourced from Uniprot.org