| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Monoclonal |
| Clone ID: | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IMPDH2 |
| Gene ID: | 3615 |
| Uniprot ID: | IMDH2_HUMAN |
| Immunogen Region: | 100-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human IMPDH2 (P12268). |
| Immunogen Sequence: | QANEVRKVKKYEQGFITDPV VLSPKDRVRDVFEAKARHGF CGIPITDTGRMGSRLVGIIS SRDIDFLKEEEHDCFLEEIM TKREDLVVAPAGITLKEANE ILQRSKKGKLPIVNEDDELV AIIARTDLKKNRDYPLASKD AKKQLLCGAAIGTHEDDKYR LDLLAQAGVDVVVLDSSQGN SIFQINMIKYIKDKYPNLQV I |
| Tissue Specificity | IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor. |
| Post Translational Modifications | Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 2 Imp Dehydrogenase 2 Impd 2 Impdh 2 Inosine-5'-Monophosphate Dehydrogenase Type Ii Imp Dehydrogenase Ii Impdh-Ii |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-73817 Reactome: R-HSA-9679191 Reactome: R-HSA-9748787 |
| Cellular Localisation | Cytoplasm Nucleus Cytosol Can Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion |
| Alternative Antibody Names | Anti-Inosine-5'-Monophosphate Dehydrogenase 2 antibody Anti-Imp Dehydrogenase 2 antibody Anti-Impd 2 antibody Anti-Impdh 2 antibody Anti-Inosine-5'-Monophosphate Dehydrogenase Type Ii antibody Anti-Imp Dehydrogenase Ii antibody Anti-Impdh-Ii antibody Anti-IMPDH2 antibody Anti-IMPD2 antibody |
Information sourced from Uniprot.org
