• Immunohistochemistry of mouse tissue with Anti-ILK primary antibody (STJ501449) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-ILK antibody (400-452) (STJ501449)

SKU:
STJ501449-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ILK (400-452) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.66-0.87 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ILK
Gene ID: 3611
Uniprot ID: ILK_HUMAN
Immunogen Region: 400-452
Immunogen: Synthetic peptide taken within amino acid region 400-452 on human Integrin-linked protein kinase.
Tissue Specificity Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Post Translational Modifications Autophosphorylated on serine residues.
Function Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Protein Name Integrin-Linked Protein Kinase
59 Kda Serine/Threonine-Protein Kinase
Beta-Integrin-Linked Kinase
Ilk-1
Ilk-2
P59ilk
Database Links Reactome: R-HSA-446343
Reactome: R-HSA-446353
Cellular Localisation Cell Junction
Focal Adhesion
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Projection
Lamellipodium
Cytoplasm
Myofibril
Sarcomere
Alternative Antibody Names Anti-Integrin-Linked Protein Kinase antibody
Anti-59 Kda Serine/Threonine-Protein Kinase antibody
Anti-Beta-Integrin-Linked Kinase antibody
Anti-Ilk-1 antibody
Anti-Ilk-2 antibody
Anti-P59ilk antibody
Anti-ILK antibody
Anti-ILK1 antibody
Anti-ILK2 antibody

Information sourced from Uniprot.org

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