Anti-IL9 antibody (19-144) (STJ24196)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL9 (19-144) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL9 |
| Gene ID | 3578 |
| Uniprot ID | IL9_HUMAN |
| Immunogen Region | 19-144 |
| Immunogen Sequence | QGCPTLAGILDINFLINKMQ EDPASKCHCSANVTSCLCLG IPSDNCTRPCFSERLSQMTN TTMQTRYPLIFSRVKKSVEV LKNNKCPYFSCEQPCNQTTA GNALTFLKSLLEIFQKEKMR GMRGKI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 19-144 of human IL9 (NP_000581.1). |
Additional Info
| Function | Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. |
| Protein Name | Interleukin-9Il-9Cytokine P40T-Cell Growth Factor P40 |
| Database Links | Reactome: R-HSA-8985947 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-9 antibodyAnti-Il-9 antibodyAnti-Cytokine P40 antibodyAnti-T-Cell Growth Factor P40 antibodyAnti-IL9 antibody |
Information sourced from Uniprot.org